RET/PTC3 Rearrangement in Papillary Thyroid Carcinoma: Possible Marker of Tumor Progression.
نویسنده
چکیده
2. J Clin Endocrinol Metab. 2016 Nov 16:jc20162555. [Epub ahead of print] Germline polymorphisms of the VEGF-pathway predict recurrence in non-advanced differentiated thyroid cancer. Marotta V(1), Sciammarella C(1), Capasso M(2), Testori A(2), Pivonello C(3), Chiofalo MG(4), Gambardella C(5), Grasso M(6), Antonino A(7), Annunziata A(8), Macchia PE(3), Pivonello R(3), Santini L(5), Botti G(8), Losito S(8), Pezzullo L(4), Colao A(3), Faggiano A(4). Author information: (1)1 IOS & COLEMAN Srl, Naples, Italy. (2)2 CEINGE Biotecnologie Avanzate, Federico II University, Naples, Italy. (3)3 Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. (4)4 Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori-IRCCS "Fondazione G. Pascale", Naples, Italy. (5)5 Department of Anesthesiologic, Surgical and Emergency Sciences, Division of General and Oncologic Surgery, Second University of Naples, Italy. (6)6 San Giovanni di Dio e Ruggi D'Aragona, Universitary Hospital, Division of General Surgery, University of Salerno. (7)7 Sant' Ottone Frangipane Hospital, Division of General Surgery, Ariano Irpino, Italy. (8)8 Department of Pathology, Istituto Nazionale per lo Studio e la Cura dei Tumori-IRCCS "Fondazione G. Pascale", Naples, Italy.
منابع مشابه
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Our research goal is to better understand the mechanisms controlling the initiation and progression of thyroid diseases. One such disease, papillary thyroid carcinoma (PTC), is the leading endocrine malignancy in the United States. Recently, a family of related fusion proteins, RET/PTC1-5, has been implicated in the early stages of PTC. Although all five members of this family have the c-RET pr...
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RET/papillary thyroid carcinoma (PTC) oncogenes, generated by recombination of the tyrosine kinase-encoding domain of RET with different heterologous genes, are prevalent in papillary carcinomas of the thyroid. Point mutations of RET cause multiple endocrine neoplasia type 2 (MEN2) familial cancer syndrome and are found in sporadic medullary thyroid carcinomas. Here, we show that ZD6474, a low ...
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ورودعنوان ژورنال:
- Annals of surgery
دوره 266 6 شماره
صفحات -
تاریخ انتشار 2017